Plenary Paper IMMUNOBIOLOGY A Caenorhabditis elegans–based assay recognizes immunoglobulin light chains causing heart amyloidosis
نویسندگان
چکیده
Department of Molecular Biochemistry and Pharmacology, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy; Amyloid Research and Treatment Center, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; Department of Medical Biotechnology and Translational Medicine University of Milan, Laboratorio Interdisciplinare Tecnologie Avanzate, Segrate, Italy; Department of Chemistry, University of Turin, Turin, Italy; Bio-imaging Unit, Department of Cardiovascular Research, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy; Renal Research Laboratory, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Cà Granda Ospedale Maggiore Policlinico and Fondazione D’Amico per la Ricerca sulle Malattie Renali, Milan, Italy; Department of Molecular
منابع مشابه
A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis.
Poor prognosis and limited therapeutic options characterize immunoglobulin light-chain (AL) amyloidosis with major heart involvement. Reliable experimental models are needed to study light-chain (LC)/heart interactions and to explore strategies for prevention of cardiac damage. We have exploited the nematode Caenorhabditis elegans as a novel tool, because its pharynx is evolutionarily related t...
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